Targeted cell differentiation: New Cytokines from Biochrom AG
Interleukin-12 subunit for T cell regulation
Interleukin-12 (IL-12) is an important cytokine in the regulation of the signalling cascade for the proliferation, activation and differentiation of T cells. It is generated naturally in humans following pathogen intrusion: The cells of the innate immune system recognise the pathogen and subsequently release various cytokines, including IL-12. IL-12 is produced recombinantly for use in cell culture.
IL-12 is a heterodimeric cytokine consisting of IL-12p40 and IL-12p35 subunits. IL-12 stimulates CD4+ cells so that these differentiate into TH1 cells which in turn mediate an immune response through TH1. This results in the cytokines IL-2 and IFN-γ being released. You will receive both IL-12 subunits from Biochrom AG.
The Biochrom AG cytokine product range includes 2000 recombinant proteins in various sizes. Biochrom AG offers all five main groups of cytokines: interferons (IFN), interleukins (IL), colony stimulating factors (CSF), tumour necrosis factors (TNF) and chemokines (CXC, CC).
The product-specific fillings vary between the standard sizes 1.2 and 5 µg, 20, 25 and 50, 100 and 500 µg vials. For many products bulk fillings are also available up to 1000 µg per vial. Individual fill sizes can be requested from an order quantity of 250 µg per product, for an additional charge.
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