21.11.2008

Biochrom AG, Europe-wide distributor of the PERMEXCIS® cell culture medium

Biochrom AG, Europe-wide distributor of the PERMEXCIS® cell culture medium

Biochrom AG and the Dutch company Crucell N.V. ratify the conclusion of a cooperation. According to this Biochrom AG is in charge of the production, sale and distribution of the PERMEXCIS® cell culture medium in the European Union, Switzerland, Turkey, Russia, and Israel. Financial details of this agreement were not announced. Crucell has developed and tested the PERMEXCIS® medium for the cultivation of PER.6® cells.

The PERMEXCIS® medium is a chemically defined, serum-free cell culture medium that does not contain animal or human origin components. The cell culture medium is apt to cultivate PER.C6® cells and applicable on large-scale productions of biopharmaceutical products like for example inoculants. The PERMEXCIS® medium increases the production of viral inoculants in PER.C6® cells compared to the cultivation in the previously used media.

“Biochrom AG is pleased about the cooperation with Crucell N.V. Biochrom AG is one of the leading European manufacturers of cell culture media and thus specialized in the production and long-term Europe-wide distribution of the PERMEXCIS® medium. We are upgrading our product range of serum-free media with a new, attractive product for cell culture”, states Dr. Wolfgang Höckh, member of the Biochrom AG Managing Board.

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Biochrom AG

Biochrom AG is one of the leading European manufacturers of cell culture media and animal sera for cell culture. Biochrom AG produces all products required for cell culture: standard media, complete media, media for special cell lines and applications, customer-specific formulated media and also animal sera, above all fetal bovine serum (FBS). All serum batches are defined concerning origin and are free from adventitious virus and mycoplasms. The complete production process of sera, media and sterile solutions meets the highest requirements of our clients from the research and biopharmaceutical production sector. Biochrom AG produces batch sizes of industry buffers of up to 4,000 liters, dry media of up to 20,000 liters and customer-specific nonstandard fillings in small units.

Crucell N.V.

Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) is a global biopharma company focused on research, development, production and marketing of vaccines, proteins and antibodies that prevent and treat infectious diseases. Its vaccines are sold in public and private markets worldwide. Crucell's core portfolio includes a vaccine against hepatitis B, a fully-liquid vaccine against five important childhood diseases and a virosome-adjuvanted vaccine against influenza. Crucell also markets travel vaccines, such as the only oral anti-typhoid vaccine, an oral cholera vaccine and the only aluminum-free hepatitis A vaccine on the market. The Company has a broad development pipeline, with several product candidates based on its unique PER.C6® production technology. The Company licenses its PER.C6® technology and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, Sanofi-Aventis, Novartis, Wyeth and Merck & Co. Crucell is headquartered in Leiden, the Netherlands, with subsidiaries in Switzerland, Spain, Italy, Sweden, Korea and the US. The Company employs over 1000 people. For more information, please visit www.crucell.com. PER.C6® and PERMEXCIS® are trademarks of Crucell Holland B.V.

By: Grit Grohmann

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